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The prevalence of cramps among individuals with chronic liver disease spans from 22 to 88%, mirroring the incidence observed in other chronic conditions such as type 1 diabetes mellitus (2434%), type 2 diabetes mellitus (4578%), and chronic kidney disease (5667%), yet markedly exceeding that of the general populace

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Finally, the development of an effective drug targeting glutamine metabolism is another challenge for the development of novel anticancer therapeutic strategies

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In the early 60s, it was theorized that multiple 5 -reductase isozymes existed 5