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Your body is adjusting to the medication, and the starting dose is deliberately low

The sudden or gradual onset of diffuse mucosal pigmentation in adulthood, even in darkerskinned patients, should alert the clinician to contemplate a pathologic genesis

2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier

doi: 10.1016/j.jdermsci.2024.02.009 19

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Buckner, R