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These include transcriptional activation (with VP64), transcriptional repression (with KRAB), epigenetic modification (using enzymes like DNMT3A), and precise base editing (with enzymes such as AID) [102]

It is part of a broader shift in how patients approach body composition: they are moving past generic weight loss conversations and into the specifics of mechanism, efficacy, and supervised care

Rotating injection sites is recommended in the SmPC to reduce the risk of injection site reactions

Cornell S

Side effects are rare and typically limited to mild, transient skin irritation or redness at the application site, particularly with higher concentrations

The cost savings are minimal compared to the risks