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Second, heterogeneity in inflammatory subtypes may exist among EDC patients, with some individuals exhibiting IL-1 -driven immune responses, while others may show predominance of TNF-, HMGB1, or NLRP3 inflammasome activation

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Unlike other agents in its class, Linagliptin exhibits a unique pharmacokinetic profile with predominantly non-renal elimination, making it suitable for patients with varying degrees of renal impairment without requiring dose adjustments

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