The trials to date have been mixed, and some experts wondered if the effects people initially reported will persist
Because the satiety-signaling mechanism is highly dose-dependent at the upper end of the titration schedule, Wegovy users should especially prioritize the abdomen as their default site to ensure they are getting the full benefit of their prescribed dose
Samms RJ, Coghlan MP, Sloop KW
According to the Rybelsus Summary of Product Characteristics (SmPC) published on the Electronic Medicines Compendium (EMC), oral bioavailability remains relatively low compared to the injectable form, and the tablet must be taken on an empty stomach with no more than half a glass of water (approximately 120 ml), with the patient remaining fasting for at least 30 minutes afterwards, to maximise absorption
By developing this in-depth understanding of the impacts of the GLP-1s on patient populations, treatment paradigms and clinician messaging, MedTech companies will be able to make informed strategic decisions to stay the course or pivot to other promising segments if needed
Scientists are looking for better options
