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After four weeks, the diameter of micro vessels at the fingertips and thus microcirculation was significantly increased in 53.8% of the patients supplemented with Pycnogenol compared to 32% of subjects of the placebo group (31)

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Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]