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Men pursuing testosterone replacement therapy (TRT) often face an unexpected challenge: weight gain that becomes harder to manage over time

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A previous in vitro study immersed the rat tail tendon in AGEs and found that the tendon texture became stiff and rigid, and the color of the Achilles tendon was changed from pearl white to gray-yellow or gray-white [42]

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To understand the multiplexed pharmacological actions of retatrutide, we used cryo-electron microscopy (cryo-EM) to determine the structures of GLP-1R, GIPR and GCGR bound to retatrutide