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It interacts with pathways like the nitric oxide (NO) system and can downregulate pro-inflammatory cytokines while protecting cells from oxidative stress

Rutaecarpine alleviates acute pancreatitis in mice and AR42J cells by suppressing the MAPK and NF-B signaling pathways via calcitonin gene-related peptide

Baietto L, Corcione S, Pacini G, Perri GD, D'Avolio A, De Rosa FG

Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-B, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine

The membrane injury detected by Evans blue uptake had significantly indicated the sensitivity of plats to peroxidation reaction under Al stress