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The reaction proceeded smoothly with both substrates bearing electron-donating group ( 5h ) and halogen-containing N -substituted phthalimides ( 5im )

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[DOI] [PubMed] [Google Scholar] 55.Leopold J

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In addition, with the rise of global profiling strategies such as metabolomics, transcriptomics and large-scale proteomics leading to further delineation of the mechanisms of action of vitamin C, future clinical trials may be designed based on more refined rationales

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