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218 However, the inhibition effect of STF-31 was partially suppressed by nicotinic acid in NAPRT positive cell lines

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For further biological evaluation, co-culture systems and reconstructed skin models should be adopted to screen for the ability of the novel compounds to interfere with the melanogenesis process, especially following stimuli including UV irradiation, exposure to a-MSH or proinflammatory cytokines

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Whole blood histamine and a plasma methylation panel measuring SAM, SAH, the SAM/SAH ratio, methionine and homocysteine provide more direct information about methylation function