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3 A spectrum of inflammatory responses and the key pathways involved An inflammatory response typically comprises four key components: inducers that initiate signaling cascades, sensors that link inducers to signaling pathways, mediators that are produced as a result of signaling, and targets that are affected by these mediators (37)

Research Diets, D12108 C, 1.25% cholesterol) or an ALC-supplemented diet (300 mg/kg, Changzhou Shuiyushuer Company, Changzhou, China) for 4 weeks ( n = 6 mice per group)

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