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Common side effects like nausea, vomiting, and diarrhea remain, and long-term safety for brain protection needs more study

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All data were analyzed using R software version 3.43, JMP version 14, or Prism (GraphPad Software)

AY has given paid lectures and sat on advisory boards for the following companies with drugs used in affective and related disorders: Flow Neuroscience, Novartis, Roche, Janssen, Takeda, Noema pharma, Compass, Astrazenaca, Boehringer Ingelheim, Eli Lilly, LivaNova, Lundbeck, Sunovion, Servier, Livanova, Janssen, Allegan, Bionomics, Sumitomo Dainippon Pharma, Sage, Neurocentrx

Beyond established pharmacological mechanisms such as improved glucose-dependent insulin secretion, delayed gastric emptying, and appetite modulation, growing evidence indicates that the intestinal microbial ecosystem may contribute to interindividual differences in treatment outcomes