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Cambridge, UK:The Royal Society of Chemistry (2015)

J Pharmacol Exp Ther 290:14821492 Yong SJ (2021) Persistent brainstem dysfunction in long-covid: a hypothesis

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In isolated myocardium, TMAO produces acute inotropic effectsenhancing calcium influx via channel potentiation, increasing myocardial contractility, and stabilizing ion channel integrity to augment excitability and sinoatrial node pacing, thereby transiently maintaining cardiac output (Oakley et al., 2020)