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GIP activation appears to complement GLP-1 effects synergistically rather than additively, which explains why Tirzepatide (dual agonist) produces significantly more weight loss than Semaglutide (single agonist) despite both activating GLP-1

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* Correspondence: Karuna Rasineni, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The multiprotein complexes of the electron transport chain correspond to the functional names: Complex I: NADH dehydrogenase complex Complex II: Succinate dehydrogenase Complex III: Cytochrome bc1 complex Complex IV: Cytochrome c oxidase complex (contains cytochromes a and a3) As seen above, the transport of electrons to oxygen is carried out by passage along an organized series of carriers that are located within the inner mitochondrial membrane

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