More Options, More Confusion With new drugs entering the market including Zepbound, compounded semaglutide, and tirzepatide patients now seek clarity
Shameless self-promotion here but we mentioned earlier along with my friend and colleague Zoe we host the podcast Breaking Down Biosimilars
Case Presentation A 63 years old woman presented with a two days history of worsening abdominal pain and distention
Accordingly, alanine mutagenesis of TM7 residues influenced both GLP-1 and oxyntomodulin affinity, but there was a larger effect on oxyntomodulin, consistent with its stronger interactions, however, interestingly these residues were more important for GLP-1-mediated cAMP production (Supplementary Figs 9, 10)
GMP (Good Manufacturing Practice) is an FDA-mandated certification
There are also concerns that semaglutide could cause a loss of muscle mass