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Commonly cited protocols (100 to 300 mcg two to three times daily) are derived from animal studies and practitioner convention, not from dose-finding RCTs in healthy human adults

doi:10.1016/j.ntt.2006.05.003 Islam Z, Amuzie CJ, Harkema JR, Pestka JJ

Many people, particularly those in northern climates or with limited sun exposure, require dietary sources or supplementation to maintain adequate vitamin D status year-round

Research Base Comparison Both compounds have substantial published research bases: AOD-9604

In patients over two years of age who are clinically suspected of having a hereditary mitochondrial disease, valproic acid should only be used after other anticonvulsants have failed

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