Unlike some medications that lose effectiveness over time, incretin-based therapies maintain efficacy in multi-year studies
FDA has observed troubling conditions during many of its inspections of compounding facilities including toaster ovens used for sterilization, pet beds near sterile compounding areas, and operators handling sterile drug products with exposed skin, which sheds particles and bacteria, says the agency
However, its main purpose is diabetes management, with weight loss considered an additional effect rather than the primary treatment aim
It's also frequently misrepresented - used to make promises about compounded products that the original trials don't support
Thymosin beta 4 is unusual in this compound class for having controlled human data, RGN-259 ophthalmic solution has been assessed in randomised, placebo-controlled, double-masked Phase 2 and Phase 3 trials in severe dry eye and neurotrophic keratopathy (Sosne et al., Cornea 2015 and Int J Mol Sci 2023)
Foundayo (Oral GLP-1) ~$149/month self-pay for Eli Lilly's oral GLP-1 (FDA approved April 1, 2026) Daily pillno injections required See our Foundayo guide 5
