The overexpression of GSTs in cancer cells offers unique opportunities for prodrug therapy 108
N-(N-gamma-Glutamyl-cysteinyl)glycine-(2,2)-disulfide
Their routine mostly includes Vitamin C, Niacinamide, Glutathione, Rice water extracts and gentle acids for skin brightening
NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies
In a 2025 review, after 1,200 mg intravenously twice a week for six weeks, 37.5% of participants reported lighter skin compared with 18.7% in the placebo group, and the effect faded after about six months
However, the predominance of rodent studies raises questions about translatability to human pathophysiology and therapeutic responses