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GLP-1 agonists, by contrast, are designed for sustained use and help maintain weight loss over years when continued

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Individual responses vary, and hydration is the most consistent and best-supported short-term effect

Unlike phentermine, Contrave has no cardiovascular stimulant effect, making it a suitable option for women who cannot take stimulant-based medications

In head-to-head analyses, tirzepatide (Zepbound) has produced the largest average weight loss roughly 20% of body weight over 72 weeks in the SURMOUNT-1 trial