CTLA -4 polymorphism (CT60) is linked to increased thyroid autoantibody production, while PTPN22 R620W variant disrupts immune tolerance, exacerbating autoreactive lymphocyte activation
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Otherwise, organ meats and seafoods are the best sources, followed by muscle meats, cereals and grains, although the selenium content of the latter varies widely with location, being towards or at the bottom of the range in the UK and Europe but at the top in North America, most notably in Canada (see Fig
Science 327 (5968): 10001004