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Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

Assami K, Pingret D, Chemat S, Meklati BY, Chemat F

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We demonstrate that the PPAR and PPAR transcriptional machinery is intact and chromatin at the sites of PPAR and PPAR binding motifs is accessible, but expression of PPAR and PPAR target genes is reduced, suggesting a deficiency of PPAR ligands in the SC-islet differentiation process