The symptoms of GERD can vary but often include heartburn, regurgitation of food or sour liquid, difficulty swallowing, coughing, and chest pain
Mechanistically, macrophage-specific inhibition of GLUL leads to accumulation of succinate and HIF-1 via glutamine-dependent -aminobutyric acid (GABA) shunting (thereby inhibiting vessel sprouting and metastasis) and via stimulation of T effector cells
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doi: 10.1016/j.redox.2021.101995
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I worked at a company called AAG in 1999 as part of a team that developed survival equipment for the United States Navy