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If an experimental drug reduces disease progression and results in less need to change symptomatic medications, an imbalance in medication changes between groups can potentially mask or underestimate the true benefits of the new therapy 8

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Diabetes, Obesity and Metabolism (2026) 3

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Covers weight loss efficacy, cardiovascular data, liver fat reduction, and regulatory status

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GLP-1R expressing cells are widely expressed in mouse and non-human primate brain (Heppner et al., 2015)

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