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These findings suggest that a regulatory circuit involving PUF-8, GLD-1, GLD-2, and MPK-1 controls the program of germline differentiation or dedifferentiation depending on gene dosage and genetic context (Figure 7)

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Specifically, BBR exerted an antioxidant effect by decreasing the generation of cardiac superoxide and gp91 phox expression, and by increasing SOD levels (Yu et al., 2016)

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