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Although clinical outcomes have varied, with some showing reductions in albuminuria and others failing to meet primary endpoints, their collective results reinforce the biological relevance of these pathways and justify continued therapeutic exploration

In clinical trials, people have lost an average 20% or more of their baseline weight, well above the typical success seen with diet and exercise alone

That is why the American Academy of Pediatrics now recommends considering pharmacotherapy as part of a comprehensive treatment approach for adolescents with obesity

Recent events have focused attention on the contribution of social determinants of health and a lack of equity in the delivery of care to disparate and unfavourable outcomes

It shields cells from external toxins, metabolic byproducts, and environmental exposure

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