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Iron overload induces ferroptosis by activating Piezo1, a pressure-sensitive calcium channel in chondrocytes, leading to subsequent calcium inflow, which could be exacerbated by conditional GPX4 knockout in cartilage

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This vascular impairment reduces nitric oxide availability, a critical molecule for smooth muscle relaxation and arterial dilation necessary for erection

So we created mathematical model of the arsenic methylation pathway which incorporates three different roles for GSH