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This triple-threat design is what differentiates it from its predecessors, which typically only targetted one or two of these receptors

Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, Sailer V, Augello M, Puca L, Rosati R, McNary TJ, Churakova Y, Cheung C, Triscott J, Pisapia D, Rao R, Mosquera JM, Robinson B, Faltas BM, Emerling BE, Gadi VK, Bernard B, Elemento O, Beltran H, Demichelis F, Kemp CJ, Grandori C, Cantley LC, Rubin MA (2017) Personalized in vitro and in vivo Cancer models to guide precision medicine

These results happened after the mice took one dosage of the peptide per day for 14 days

Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway

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Source Data Extended Data Fig./Table 1 (download XLSX Statistical source data