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Evidence Behind Semaglutide and Tirzepatide Efficacy in Real-World Use Clinical trials demonstrate semaglutide achieves average weight loss of 9-17% at maintenance doses, with higher percentages in longer studies

This increases each week for five weeks until you reach the maximum dose of 3 mg

Nearly all (95.4%, 95% CI 93.5-96.9) achieved 5% body weight loss, 82.0% achieved 10% body weight loss (95% CI 78.8- 84.9), and 32.8% achieved 20% body weight loss (95% CI 29.2-36.6) over the study period

doi:10.7759/cureus.31425

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These results suggest that activation of 5-HT transmission by FLX attenuates the impairment of sociability and object recognition memory in prenatal VPA mice