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Antioxidant properties of glutathione may interfere with the activity of radiation therapy and some chemotherapy drugs

To further identify the specific HDAC isoform that was involved in regulating GLP-1R expression, isoform-specific HDAC inhibitors were used

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in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )