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These associations remained consistent across subgroup analyses, including patients using tirzepatide as adjunctive therapy to other first-line diabetes agents, among patients older than 60 and comparisons against individual GLP-1 drugs, including semaglutide and dulaglutide

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Once released, natural GLP1 does several things simultaneously: Stimulates insulin secretion : GLP1 signals pancreatic beta cells to release insulin, but only when blood sugar is elevated