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Exclusion criteria for participation included contraindications to MRI, inability to read or understand English, concussion within the past three months, neurological, psychiatric, or systemic disorders (e.g., attention deficit hyperactivity disorder (ADHD), autism, developmental delay, intellectual disability psychosis, schizophrenia) or major comorbidities such as epilepsy or arthritis

d , Reversal of arthritis-induced allodynia and hyperalgesia by oral administrations of TYK2 inhibitor (Deucravacitinib, 15 mg/kg, twice daily, day13-day21, n = 5 or 6 per group)