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Injection of FOXO4-DRI in both naturally aged and induced-aging mice suppressed aortic aging and improved aortic function while alleviating endothelial cell senescence (PMID: 41625068)

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10.1016/j.pharep.2015.11.004 33 MateiD

As illustrated in Figure 1, adipocyte-derived leptin signals peripheral energy status to the arcuate nucleus (ARC) of the hypothalamus

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