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Whereas GLP-1 decreases plasma glucose levels by exerting insulinotropic effects, glucagon stimulates hyperglycemia by enhancing hepatic glucose output

10.1038/cr.2016.100 28 ChenY.FangZ.-M.YiX.WeiX.JiangD.-S

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Diabetic neuropathy benefits Perhaps most relevant to the semaglutide discussion, research demonstrates that GLP-1 receptor agonists can ameliorate diabetic neuropathic pain by inhibiting neuroinflammation in the spinal cord

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Due to age-related growth hormone synthesis decline, older persons may benefit from a customized peptide regimen that accounts for these physiological changes