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Such inhibition curtails the efficient excretion of uremic toxins (including pCS), thus perpetuating a vicious cycle of toxin accumulation, heightened systemic inflammation, and progressive renal injury (30).Additionally, IS and p-cresyl sulfate activate the pro-fibrotic TGF-1/Smad3 pathway, increasing renal cortical TGF-1 expression approximately 3.2-fold and promoting interstitial fibrosis, effects that are abrogated by selective AhR antagonism (18, 31, 32)

A: Most conservative protocols recommend cycling (812 weeks on, 46 weeks off)

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05 Safety Information & Contraindications