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5 Pharmacological effects of GIP, GLP-1 and their mimetics The pharmacological benefits of GIP, GLP-1, and their synthetic mimetics arise from their pleiotropic effects, encompassing at least five key functions: bolstering insulin secretion and survival of pancreatic -cells and modulating glucagon release by the pancreatic -cells in response to glycemic levels, acting on the satiety center in brain, slowing gastric emptying, regulating lipid and glucose metabolism through effects on adipose tissue and liver, and reducing systemic blood pressure
What are GLP-1 agonists and antagonists, and how do they work
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How is Retatrutide administered
Depending on the specific drug, injections may be required: Once daily (e.g., liraglutide) Once weekly (e.g., semaglutide, dulaglutide) Most patients find the injection process straightforward after initial training from a practice nurse or diabetes specialist nurse
J Clin Endocrinol Metab (2002) 87(3):123946
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