In another trial, patients who reduced their Zepbound dose to a lower 5 mg maintenance dose also preserved much of their earlier weight reduction compared with those who stopped treatment entirely
Secondary outcome measurements included reduction in body weight from baseline by at least 5% or 10% by week 26, changes in waist circumference, total cholesterol, HDL, LDL, VLDL, and triglycerides, and levels of different glycemic variables including HbA1C, fasting plasma glucose, fasting insulin, insulin resistance, and the functioning of beta-cells
Treatment-related considerations specific to semaglutide therapy include: Gastrointestinal adverse effects : Persistent nausea, vomiting, or diarrhea leading to inadequate fluid replacement creates a state of relative dehydration
PMID 40461817
Eli Lilly, the maker of Zepbound, announced Tuesday it will begin selling the weight loss drug directly to consumers through the company's direct pharmacy, LillyDirect
However, some individuals may experience mild side effects such as gastrointestinal discomfort or allergic reactions