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If considering use beyond this period, particularly at doses providing more than 25 mg of elemental zinc daily, clinical review is advisable and monitoring for copper status may be appropriate in long-term use

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Additionally, GLP-1 RAs modulate the hypothalamus (the region in the brain that controls appetite) to regulate hunger, slow gastric emptying, and regulate gut hormones such as leptin (a hormone that helps regulate body weight on a long-term basis)

Tirzepatide, a dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist, has further expanded the incretin-based treatment landscape

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