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The Current Status of GLP-1s in Canada Health Canada has approved several GLP-1 medications for use

Observational studies in humans report lower circulating spexin levels in obesity and metabolic syndrome, supporting its role as an endogenous metabolic regulator rather than a stress-induced peptide (Lv et al., 2019)

Statements Author contributions BG: Writing original draft

Association learning is impaired in insulin resistance and restored by liraglutide

Other GLP-1 Pills in the Pipeline Although Wegovy is the first GLP-1 pill the FDA has approved for weight management, drug manufacturers are funding trials for additional oral GLP-1 medications

Most tolerate long-term with tweaks, achieving glycemic control and heart protection