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Dr Emma Wedgeworth, consultant dermatologist and British Skin Foundation spokesperson, helps explain

Lean mass loss was reported for patients on semaglutide (~10% loss relative to baseline) and tirzepatide (~11% loss relative to baseline) during Phase III clinical trials, STEP-1, NCT03548935 and SURMOUNT-1, NCT04184622, respectively 61, 62

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Examining specific fracture sites revealed non-significantly reduced risk of fractures of the humerus and of the spine with GLP-1 RAs compared to DPP-4is

The majority of reported NPIs for applications with multiple NPIs were active