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The current medications that the FDA has approved are orlistat (Xenical), phentermine/topiramate (Qsymia), naltrexone/bupropion (Contrave), liraglutide (Saxenda), and semaglutide (Wegovy) for long-term use in weight loss

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GLP-1 RAs have been found to have vasodilatory and anti-atherosclerotic effects in animal models and some human studies