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Reducing stress, anxiety, and other factors like poor sleep, dehydration, or side effects from medications can also help lessen muscle twitching

doi: 10.1007/s10787-017-0358-8

Published human evidence remains too limited to confirm those widely promoted uses

Immobilization aids like slings or walking boots might be necessary to minimize movement while safeguarding the treated joint

The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings

Soon, the gray market expanded beyond gym subcultures