Li et al., 2021a
aleniglipron and orforglipron) are functionally Gs-biased and recruit -arrestin poorly (which is typically involved in turning off the GLP-1 receptor's signal by promoting internalization and downregulation and mediating nausea and vomiting)
One non-prescription option gaining attention is Motus, an oral supplement from Tonum that was tested in human clinical trials and reported about 10.4% average weight loss over six months, with most of the lost mass being fat
Add the cost of regular bloodwork (comprehensive panels every 2 to 4 weeks initially), body composition scans, and any medical consultation, and the total monthly investment becomes substantial
Aim for lean sources like chicken, fish, tofu, and beans
If you develop symptoms such as unusual fatigue, muscle weakness, numbness or tingling, hair loss, or mood changes, contact your GP as these may indicate nutritional deficiencies requiring investigation and targeted treatment