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It is important to note that such violations may suggest low oral bioavailability (due to high molecular weight or excessive lipophilicity), solubility limitations (reflected in Log S and TPSA values, leading to poor dissolution), inadequate permeability, an increased risk of toxicity or adverse effects, and/or a reduced likelihood of clinical success

This is because it helps us pee more and might lower oxalate levels in urine

doi:10.1080/13813450701661198 Deepmala, Slattery J, Kumar N, et al

Shergold, A

10.1017/s0029665114000482 28 KoliadaA.MoseikoV.RomanenkoM.PivenL.LushchakO.KryzhanovskaN.et al (2020)

doi:10.1002/jor.21107