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[25] With increasing numbers of proliferating stem cells in the germ line, NAD+ repletion greatly prolonged lifespan and postponed the onset of accelerated aging in animal models

doi: 10.3389/fphar.2025.1712903 Received 25 September 2025 Revised 17 November 2025 Accepted 05 December 2025 Published 08 January 2026 Volume 16 - 2025 Edited by Xiufang Huang, Guangzhou University of Chinese Medicine, China Reviewed by Adnan Amin, Yeungnam University, Republic of Korea Hua Yang, China Pharmaceutical University, China Updates Copyright 2026 Ma, Cao, Yang, Zhu, Wang, Liu, Chen, Liu and Zhang

Disturbance of this equilibrium may contribute to various immunological disorders

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Treatment with vitamin B-12 increased serum total vitamin B-12, serum holoTC, and c-B12, and reduced plasma tHcy and serum MMA ( P 50% lower holoTC concentration compared with vitamin B-12deficient participants with nonelevated folate ( Figure 8 A)