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However, their effectiveness often hinges on the integration of accompanying lifestyle changes

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Resveratrol activates the Nrf2 pathway, leading to increased expression of antioxidant enzymes and enhanced cellular protection against oxidative damage [219]

Pros: One-time treatment Long-term weight loss supported by decades of research Often improves diabetes, blood pressure, and sleep apnea No lifelong medication costs Cons: Requires surgery and recovery Lifestyle changes are necessary For many patients with severe obesity, bariatric surgery remains the most effective long-term treatment available