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GMS activation with transmembrane domain ligands *

Rao et al., 2025)

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Preclinical models used oral dosing at 50100mg/kg body weight, but human-equivalent subcutaneous protocols typically range from 30mg to 50mg per injection, administered once daily

MHR in the same cells was evaluated by a spectrophotometric assay described by Board and Pidcock (1981), expressed as mol/g Hb/min, and ACP1 activity was measured by the method of Magenis, et al