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While some weight regain is common after discontinuing weight loss medications, proactive strategies can help minimize the extent of regain and support long-term weight management

Notably, LPS-induced NF-B activation occurs in two phases: an early phase (0.5-2 hours after stimulation) driven by TLR4 signaling, and a late phase (8-12 hours after stimulation) sustained by cytokines such like TNF- and IL-1 generated during the early phase (81)

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