Metformin improves endothelial function and reduces systemic inflammation, while semaglutide decreases arterial stiffness and improves lipid profiles
Eduardo Grunvald, an obesity medicine physician at UC San Diego Health
And this is the most difficult part of the withdrawal process
This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months
The Hidden Cost of Symptom Suppression When these protective reserves decline, the body becomes less capable of neutralizing oxidative stress, repairing damaged tissues, regulating inflammation, and defending against toxins and infections
While primarily associated with gastrointestinal side effects, some patients report emotional changes including mood swings, tearfulness, or low mood whilst taking this medication