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401 In vivo inducible gene systems have also been developed to achieve precise spatial and temporal control of autophagic flux in animal models

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The marked increases in protein levels of BNIP3, P62, and PARKIN were clearly observed in the tibialis anterior muscle of mice with castration (112), and the increased ratio of LC3 II/LC3 I in mice with hypogonadism, which indicates a strong association between androgen deficiency and enhancement of mitophagy (113)