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These purified HBs demonstrated robust self-renewal capacity, expanding in a small-molecule-defined medium (ACDFSV) for over 20 passages without losing their proliferative capacity or characteristic morphology

In experimental systems, DSIP has been explored for its potential ability to influence the stability and duration of these delta-dominant sleep cycles

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However, current challenges, such as the lack of tissue-specific targeting of copper-modulating agents and interspecies differences in preclinical models, necessitate further refinement of therapeutic strategies